Evaluation of the efficacy of a 3.2% glutaraldehyde product for disinfection of fibreoptic endoscopes with an automatic machine

被引:8
作者
Akamatsu, T
Tabata, K
Hironaga, M
Uyeda, M
机构
[1] KYUSHU KOUSEI NENKIN HOSP,CENT CLIN LAB,NISHI KU,KITAKYUSHU,FUKUOKA 806,JAPAN
[2] KUMAMOTO UNIV,FAC PHARMACEUT SCI,KUMAMOTO 862,JAPAN
关键词
3.2% alkaline glutaraldehyde; fibreoptic endoscopes; automatic machine; disinfection;
D O I
10.1016/S0195-6701(97)90167-5
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The efficacy of 'Cider Plus' 3.2% alkaline glutaraldehyde was evaluated for the disinfection of fibreoptic endoscopes. The glutaraldehyde concentration in 'Cider Plus', stored in an automatic machine (Olympus EW-20), remained higher than 2% (2.21%) even after a total of 102 disinfection cycles during 28 consecutive days. The results of the in-vitro study on antimicrobial activity showed that this alkaline glutaraldehyde product had a greater activity against 20 test organisms, including vegetative bacteria, bacterial spores, mycobacteria, and fungi, than 2% glutaraldehyde alone. The presence of 10 or 30% human serum did not appear to affect the activity of glutaraldehyde adversely. Instrument samples made from a variety of materials such as stainless steel, glass, teflon, etc. were not damaged after 168 h of immersion in alkaline glutaraldehyde, although it contained approximately 1.7 times more glutaraldehyde than 2% glutaraldehyde alone. Based on these results, 3.2% alkaline glutaraldehyde is considered to be a more effective disinfectant for fibreoptic endoscopes, with the use of an automatic machine, than 2% glutaraldehyde.
引用
收藏
页码:47 / 57
页数:11
相关论文
共 17 条
[1]  
AKAMATSU T, 1995, JPN J TOX ENV HEALTH, V41, P134
[2]   NOSOCOMIAL INFECTIONS FROM CONTAMINATED ENDOSCOPES - A FLAWED AUTOMATED ENDOSCOPE WASHER - AN INVESTIGATION USING MOLECULAR EPIDEMIOLOGY [J].
ALVARADO, CJ ;
STOLZ, SM ;
MAKI, DG .
AMERICAN JOURNAL OF MEDICINE, 1991, 91 :S272-S280
[3]   ALKALINIZED GLUTARALDEHYDE NEW ANTIMICROBIAL AGENT [J].
BORICK, PM ;
DONDERSHINE, FH ;
CHANDLER, VL .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (10) :1273-+
[4]  
BUYNAK EB, 1976, P SOC EXP BIOL MED, V151, P694, DOI 10.3181/00379727-151-39288
[5]  
DAWSON DJ, 1982, AM REV RESPIR DIS, V126, P1095
[6]   Concerning the breakdown of cyclopentenes into semi aldehydes of glutaric acid or to glutaric dialdehyde. [J].
Harries, C ;
Tank, L .
BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1908, 41 :1701-1711
[7]  
Hawkey P M, 1981, J Hosp Infect, V2, P373, DOI 10.1016/0195-6701(81)90071-2
[8]  
KOGA T, 1987, J JAP SOC BRONCHOL, V9, P16
[9]  
KOGA T, 1986, J JAP SOC BRONCHOL, V8, P338
[10]  
MAUPAS P, 1976, LANCET, V1, P1367