Contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats

被引：18

作者：

Bileviciute-Ljungar, I ^{[1
]}

Lundeberg, T

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[2] Karolinska Hosp, Dept Surg, S-17176 Stockholm, Sweden

来源：

NEUROREPORT | 2000年 / 11卷 / 02期

关键词：

contralateral treatment; local anaesthetics; neuropathic pain; nociception; rats;

D O I：

10.1097/00001756-200002070-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present study was to establish whether contralateral treatment with local anaesthetics reduces nociceptive behaviour in mononeuropathic rats. Contralateral treatment with xylocaine on day 6 and 11 following sciatic nerve ligation increased withdrawal latencies to thermal but not to mechanical stimulation for 3-4 days. Rats who received contralateral treatment with xylocaine on day 6 and 11 showed a reduced autotomy score during the following 6 weeks. To compare ipsilateral and contralateral effects another set of experiments was performed. Rats treated contralaterally on day 11 had a significantly lower autotomy score at week 4 and 6. Our results demonstrate that contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats for days or weeks. NeuroReport 11:291-295 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：291 / 295

页数：5

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