The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

被引：21

作者：

August, A

Fischer, A

Hao, S

Mueller, C

Ragin, M

机构：

[1] Penn State Univ, Immunol Res Labs, University Pk, PA 16802 USA

[2] Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

[3] Penn State Univ, Grad Program Pathobiol, University Pk, PA 16802 USA

[4] Penn State Univ, Grad Program Cell & Dev Biol, University Pk, PA 16802 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2002年 / 34卷 / 10期

关键词：

ITK; Rlk; Txk; BTK; T cell activation; B cell activation;

D O I：

10.1016/S1357-2725(02)00068-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1184 / 1189

页数：6

共 15 条

[1] CD28 IS ASSOCIATED WITH AND INDUCES THE IMMEDIATE TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE TEC FAMILY KINASE ITK/EMT IN THE HUMAN JURKAT LEUKEMIC T-CELL LINE [J].