Effects of neurosteroids on ischemia-reperfusion injury in the rat retina:: role of σ1 recognition sites

被引：52

作者：

Bucolo, C ^{[1
]}

Drago, F ^{[1
]}

机构：

[1] Univ Catania, Sch Med, Dept Expt & Clin Pharmacol, I-95125 Catania, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 498卷 / 1-3期

关键词：

neurosteroid; sigma(1) recognition site; retina; neuroprotection;

D O I：

10.1016/j.ejphar.2004.06.067

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of neurosteroids, 17beta-estradiol and dehydroepiandrosterone-sulfate (DHEA-S), were investigated on retinal degeneration using a rat model of ischemia-reperfusion injury. The animals were anaesthetized and retinal ischemia was induced by elevating the intraocular pressure to 120 mm Hg for 45 min. Neurosteroids were injected intraperitoneally before ischemia and immediately after reperfusion. Retinal biochemical changes such as increase of lactate content and decrease of glucose and ATP were significantly inhibited by neurosteroids compared to the control ischemic group. The effects of 17beta-estradiol and DHEA-S were antagonized by pre-treatment with the sigma(1) site antagonist. These findings suggest that 17beta-estradiol and dehydroepiandrosterone-sulfate may affect the metabolic state of surviving neurons and glial cells after ischemic injury and that they act, at least in part, through involvement of a, recognition sites. (C) 2004 Elsevier B.V All rights reserved.

引用

页码：111 / 114

页数：4

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