Localized single-stranded bubble mechanism for cyclization of short double helix DNA

被引：224

作者：

Yan, J ^{[1
]}

Marko, JF ^{[1
]}

机构：

[1] Univ Illinois, Dept Phys, Chicago, IL 60607 USA

来源：

PHYSICAL REVIEW LETTERS | 2004年 / 93卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.93.108108

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Recent experiments indicate that double-stranded DNA molecules of approximately 100 base pairs in length have a probability of cyclization which is up to 10(5) times larger than that expected based on the known bending modulus of the double-helix. We argue that for short molecules, the formation of a few base pairs of single-stranded DNA can provide a "flexible hinge" that facilitates loop formation. A detailed calculation shows that this mechanism explains the experimental data.

引用

页码：108108 / 1

页数：4

共 16 条

[1] Spontaneous sharp bending of double-stranded DNA [J].