Gait analysis in a rat model of osteoarthrosis

被引:74
作者
Clarke, KA [1 ]
Heitmeyer, SA [1 ]
Smith, AG [1 ]
Taiwo, YO [1 ]
机构
[1] PROCTER & GAMBLE CO,MIAMI VALLEY LABS,CINCINNATI,OH 45239
关键词
gait; rat; osteoarthrosis; locomotion; animal model;
D O I
10.1016/S0031-9384(97)00022-X
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Gait analysis has been undertaken in a rat model of osteoarthrosis, induced by intra-articular injection of sodium iodoacetate into the left knee. Two weeks after injection, no disturbances were recorded to the velocity of locomotion, the stride length nor the stride, stance, or swing times. However, clear and consistent reductions in the peak vertical load bearing (P-z) by the affected limb were observed of 22-29% relative to the other limbs, with the right forelimb taking the major share of extra load. This redistribution fitted well with the gait pattern of the rat, allowing P-z redistribution with minimum gait disturbance, and was still present 6 weeks later. These results are discussed in the context of the possible load sensitivity of the damage process to the gait pattern of the rat. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:951 / 954
页数:4
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