Loss of oxyR in Mycobacterium tuberculosis

被引：42

作者：

Deretic, V

Song, J

PaganRamos, E

机构：

[1] Dept. of Microbiology and Immunology, 5641 Medical Science Building II, Univ. of Michigan Medical School, Ann Arbor

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(97)01112-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The loss of the putative regulator oxyR and the associated dysfunction of oxidative stress response in Mycobacterium tuberculosis may have coincided with, or directly participated in, the evolution of this microorganism into the potent contemporary human pathogen. These phenomena may have implications for host-pathogen interactions in tuberculosis and for M. tuberculosis sensitivity to the front-line antituberculosis agent isoniazid.

引用

页码：367 / 372

页数：6

共 49 条

[1] TUBERCULOSIS - COMMENTARY ON A REEMERGENT KILLER
BLOOM, BR
MURRAY, CJL
[J]. SCIENCE, 1992, 257 (5073) : 1055 - 1064
[2] How do macrophages distinguish the living from the dead?
Cheers, C
Zhan, Y
[J]. TRENDS IN MICROBIOLOGY, 1996, 4 (11) : 453 - 455
[3] POSITIVE CONTROL OF A REGULON FOR DEFENSES AGAINST OXIDATIVE STRESS AND SOME HEAT-SHOCK PROTEINS IN SALMONELLA-TYPHIMURIUM
CHRISTMAN, MF
MORGAN, RW
JACOBSON, FS
AMES, BN
[J]. CELL, 1985, 41 (03) : 753 - 762
[4] MYCOBACTERIUM-TUBERCULOSIS IS A NATURAL MUTANT WITH AN INACTIVATED OXIDATIVE-STRESS REGULATORY GENE - IMPLICATIONS FOR SENSITIVITY TO ISONIAZID
DERETIC, V
PHILIPP, W
DHANDAYUTHAPANI, S
MUDD, MH
CURCIC, R
GARBE, T
HEYM, B
VIA, LE
COLE, ST
[J]. MOLECULAR MICROBIOLOGY, 1995, 17 (05) : 889 - 900
[5] The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid
Deretic, V
PaganRamos, E
Zhang, YQ
Dhandayuthapani, S
Via, LE
[J]. NATURE BIOTECHNOLOGY, 1996, 14 (11) : 1557 - 1561
[6] Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M-aurum and M-tuberculosis
Dhandayuthapani, S
Zhang, Y
Mudd, MH
Deretic, V
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (12) : 3641 - 3649
[7] Interactions of OxyR with the promoter region of the oxyR and ahpC genes from Mycobacterium leprae and Mycobacterium tuberculosis
Dhandayuthapani, S
Mudd, M
Deretic, V
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (07) : 2401 - 2409
[8] An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response
Dussurget, O
Rodriguez, M
Smith, I
[J]. MOLECULAR MICROBIOLOGY, 1996, 22 (03) : 535 - 544
[9] Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: Role of phagocytosis
Fulton, SA
Johnsen, JM
Wolf, SF
Sieburth, DS
Boom, WH
[J]. INFECTION AND IMMUNITY, 1996, 64 (07) : 2523 - 2531
[10] Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression
Gong, JH
Zhang, M
Modlin, RL
Linsley, PS
Iyer, D
Lin, YG
Barnes, PF
[J]. INFECTION AND IMMUNITY, 1996, 64 (03) : 913 - 918

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