Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

被引：160

作者：

Sennvik, K

Fastbom, J

Blomberg, M

Wahlund, LO

Winblad, B

Benedikz, E ^{[1
]}

机构：

[1] Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, S-14186 Huddinge, Sweden

来源：

NEUROSCIENCE LETTERS | 2000年 / 278卷 / 03期

关键词：

amyloid precursor protein; Alzheimer's disease; cerebrospinal fluid; secretase; metabolism; Western blot;

D O I：

10.1016/S0304-3940(99)00929-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alternative cleavage of the amyloid precursor protein (APP) results in generation and secretion of both soluble APP (sAPP) and beta-amyloid (A beta). A beta is the main component of the amyloid depositions in the brains of Alzheimer's disease (AD) patients. Using Western blotting, we compared the levels of alpha-secretase cleaved sAPP, beta-secretase cleaved sAPP and total sAPP, in cerebrospinal fluid (CSF) from 13 sporadic AD patients and 13 healthy controls. Our findings show significant amounts of beta-secretase cleaved sAPP in CSF. There was no statistically significant difference in the levels of beta-secretase cleaved sAPP between AD patients and controls. The levels of alpha-secretase cleaved sAPP and total sAPP were, however, found to be significantly lower in the AD patients than in the controls. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：169 / 172

页数：4

共 16 条

[1] Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation [J].