共 16 条
Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients
被引:159
作者:

Sennvik, K
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机构: Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden

Fastbom, J
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h-index: 0
机构: Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden

Blomberg, M
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h-index: 0
机构: Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden

Wahlund, LO
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h-index: 0
机构: Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden

Winblad, B
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h-index: 0
机构: Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden

Benedikz, E
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h-index: 0
机构:
Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden
机构:
[1] Karolinska Inst, NEUROTEC, KFC NOVUM, Div Geriatr Med, S-14186 Huddinge, Sweden
[2] Huddinge Univ Hosp, S-14186 Huddinge, Sweden
关键词:
amyloid precursor protein;
Alzheimer's disease;
cerebrospinal fluid;
secretase;
metabolism;
Western blot;
D O I:
10.1016/S0304-3940(99)00929-5
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Alternative cleavage of the amyloid precursor protein (APP) results in generation and secretion of both soluble APP (sAPP) and beta-amyloid (A beta). A beta is the main component of the amyloid depositions in the brains of Alzheimer's disease (AD) patients. Using Western blotting, we compared the levels of alpha-secretase cleaved sAPP, beta-secretase cleaved sAPP and total sAPP, in cerebrospinal fluid (CSF) from 13 sporadic AD patients and 13 healthy controls. Our findings show significant amounts of beta-secretase cleaved sAPP in CSF. There was no statistically significant difference in the levels of beta-secretase cleaved sAPP between AD patients and controls. The levels of alpha-secretase cleaved sAPP and total sAPP were, however, found to be significantly lower in the AD patients than in the controls. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码:169 / 172
页数:4
相关论文
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