Obesity and renal cancer Role of adipokines in the tumor-immune system conflict

被引：63

作者：

Gati, Asma ^{[1
]}

Kouidhi, Soumaya ^{[1
]}

Marrakchi, Raja ^{[1
]}

El Gaaied, Amel ^{[1
]}

Kourda, Nadia ^{[2
]}

Derouiche, Amine ^{[3
]}

Chebil, Mohamed ^{[3
]}

Caignard, Anne ^{[4
]}

Perier, Aurelie ^{[4
]}

机构：

[1] Univ Tunis El Manar, Fac Sci Tunis, Dept Biol, Lab Genet, El Manar Tunis, Tunisia

[2] Hop Charles Nicolle, Serv Histopathol, Tunis, Tunisia

[3] Hop Charles Nicolle, Serv Urol, Tunis, Tunisia

[4] Univ Paris 05, CNRS UMR 8104, U1016, INSERM,Inst Cochin, Paris, France

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

adipokines; immune response; renal cell carcinoma; obesity; NATURAL-KILLER-CELLS; WHITE ADIPOSE-TISSUE; BODY-MASS INDEX; ADIPONECTIN LEVELS; OVER-EXPRESSION; GENE-EXPRESSION; T-LYMPHOCYTES; SERUM LEPTIN; FEMALE MICE; CARCINOMA;

D O I：

10.4161/onci.27810

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose tissue in renal carcinogenesis is therefore of major importance for the development of novel paradigms of RCC prevention and treatment. Here, we discuss the current knowledge on the impact of obesity on the development and progression of RCC as well as the role of adipose tissue-derived hormones (adipokines) in the conflict between growing tumors and the immune system.

引用

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