Adrenaline cells of the rat adrenal cortex and medulla contain renin and prorenin

被引:22
作者
Berka, JL
Kelly, DJ
Robinson, DB
Alcorn, D
Marley, PD
Fernley, RT
Skinner, SL
机构
[1] UNIV MELBOURNE, DEPT ANAT & CELL BIOL, PARKVILLE, VIC 3052, AUSTRALIA
[2] UNIV MELBOURNE, DEPT PHARMACOL, PARKVILLE, VIC 3052, AUSTRALIA
[3] UNIV MELBOURNE, HOWARD FLOREY INST EXPTL PHYSIOL & MED, PARKVILLE, VIC 3052, AUSTRALIA
基金
英国医学研究理事会;
关键词
paracrine function; tissue renin; chromaffin cells; transgenic Ren-2 rat;
D O I
10.1016/0303-7207(96)03808-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The distribution and content of renin in Sprague-Dawley (SD) and transgenic (mREN-2)27 rats (TG) were compared to further define the cellular basis and function of the adrenal renin-angiotensin system. Antibody binding (to rat and mouse renin protein and prosequence) was visualised in serial paraffin sections using an avidin-biotin peroxidase technique. Chromaffin and adrenaline cells were identified by tyrosine hydroxylase (TI-I) and phenylethanolamine N-methyltransferase immunoreactivity, respectively. In SD zona glomerulosa (ZG), renin and its prosequence localised to small steroid cells while in homozygous (receiving lisinopril) and heterozygous (untreated) TG, steroid cells labelled in all cortical zones. In addition, throughout the cortex of each strain, large polyhedral adrenaline chromaffin cells occurring singly or in small groups and occasionally in rays labelled for renin and prosequence. Similar large adrenaline cells immunolabelled for all antisera in medulla while other cells were only TH-positive. Total adrenal renin content was 53 times higher in heterozygous transgenics than SD rats and was mainly (74%) prorenin. In SD, 37% of cortical renin was prorenin but in adrenal medulla only active renin was detected. Thus, from present and previous work both renin and prorenin occur not only in mitochondrial dense bodies of the ZG, but also in secretory granules of adrenaline chromaffin cells in both cortex and medulla implying in situ synthesis and paracrine functions.
引用
收藏
页码:175 / 184
页数:10
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