The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS

被引:217
作者
Millonig, JH [1 ]
Millen, KJ [1 ]
Hatten, ME [1 ]
机构
[1] Rockefeller Univ, Dev Neurobiol Lab, New York, NY 10021 USA
关键词
D O I
10.1038/35001573
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the vertebrate central nervous system (CNS), a cascade of signals that originates in the ectoderm adjacent to the neural tube is propagated by the roof plate to dorsalize the neural tube(1). Here we report that the phenotype of the spontaneous neurological mutant mouse dreher (dr)(2-5) results from a failure of the roof plate to develop. Dorsalization of the neural tube is consequently affected: dorsal interneurons in the spinal cord and granule neurons in the cerebellar cortex are lost, and the dorsal vertebral neural arches fail to form. Positional cloning of dreher indicates that the LIM homeodomain protein, Lmx1a, is affected in three different alleles of dreher. Lmx1a is expressed in the roof plate dong the neuraxis during development of the CNS. Thus, Lmx1a is required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
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页码:764 / 769
页数:6
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