The effect of cadmium exposure and stress on plasma cortisol, metallothionein levels and oxidative status in rainbow trout (Oncorhynchus mykiss) liver

被引：53

作者：

Tort, L ^{[1
]}

Kargacin, B ^{[1
]}

Torres, P ^{[1
]}

Giralt, M ^{[1
]}

Hidalgo, J ^{[1
]}

机构：

[1] UNIV ZAGREB,INST MED RES & OCCUPAT HLTH,ZAGREB,CROATIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1996年 / 114卷 / 01期

关键词：

cortisol; metallothionein; cadmium; stress; glutathione; lipid peroxidation; Zn; rainbow trout;

D O I：

10.1016/0742-8413(95)02107-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selected variables related to the stress response in mammals, such as cortisol, metallothionein (MT), glutathione (GSH) and lipid peroxidation measured as thiobarbituric acid-reactants (TBARs) were evaluated in rainbow trout in order to establish whether chemical stress by cadmium exposure or physical stress by handling cause a significant response and comparable effects between stressors. The results obtained show about three times higher levels of liver MT in fish exposed to cadmium as compared to controls and twice as high after stress, whereas plasma cortisol levels increased significantly both after stress and cadmium exposure. This indicates that both MT and cortisol were sensitive indexes to stress in this species. In contrast, liver cytosolic GSH was affected only by cadmium treatment and liver TBARs remained unaffected.

引用

页码：29 / 34

页数：6

共 42 条

[1] EFFECT OF CADMIUM CHLORIDE ON HEPATIC LIPID-PEROXIDATION IN MICE [J].