A new approach towards the synthesis of 3-amino-6-(hetero)arylpyridazines based on palladium catalyzed cross-coupling reactions

被引：61

作者：

Maes, BUW

Lemière, GLF

Dommisse, R

Augustyns, K

Haemers, A

机构：

[1] Univ Antwerp, RUCA, Dept Chem, B-2020 Antwerp, Belgium

[2] Univ Instelling Antwerp, Dept Med Chem, B-2610 Wilrijk, Belgium

来源：

TETRAHEDRON | 2000年 / 56卷 / 12期

关键词：

palladium and compounds; Suzuki reactions; Stille reactions; pyridazines;

D O I：

10.1016/S0040-4020(00)00083-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3-amino-6-(hetero)arylpyridazines via palladium catalyzed cross-coupling reactions (Suzuki, Stille) on 3-amino-6-chloropyridazine (1a) and 3-amino-6-iodopyridazine (1b) has been investigated. Comparison of the results shows that there is no need to start from 1b. An improved method for the synthesis of compound 1b from 1a is also described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1777 / 1781

页数：5

共 37 条

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ABE Y, 1978, HETEROCYCLES, V9, P1397

[2]

Albright J.D., 1986, Patent No. 4569934

[3] USE OF ALPHA-(ARYL)-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) IN 1,4-ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS AND NITRILES - VERSATILE SYNTHETIC ROUTE TO 6-ARYL-3(2H)PYRIDAZINONES [J].