The origin and specification of cortical interneurons

被引：719

作者：

Wonders, Carl P.

Anderson, Stewart A. ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY 10021 USA

[2] Cornell Univ, Grad Program Neurosci, New York, NY 10021 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn1954

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GABA-containing interneurons are crucial to both the development and function of the cerebral cortex. Unlike cortical projection neurons, which have a relatively conserved set of characteristics, interneurons include multiple phenotypes that vary on morphological, physiological and neurochemical axes. This diversity, and the relatively late, context-dependent maturation of defining features, has challenged efforts to uncover the transcriptional control of cortical interneuron development. Here, we discuss recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons.

引用

页码：687 / 696

页数：10

共 130 条

[1] NG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus [J].