PSORS1: Linking genetics and immunology

被引：45

作者：

Elder, James T. ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Dept Dermatol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2006年 / 126卷 / 06期

关键词：

D O I：

10.1038/sj.jid.5700357

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Previous studies have localized the psoriasis susceptibility 1 (PSORS1) locus to the proximal major histocompatibility complex class I region, but approximately a dozen genes in the candidate region have thus far been genetically inseparable. According to a team of researchers in the United States and Germany, the primary genetic association has now been worked out, implicating HLA-Cw6 "after all." The results integrate genetics and immunology, further reinforcing our emerging understanding of psoriasis.

引用

页码：1205 / 1206

页数：2

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