Addressing the Challenges of the Clinical Application of Pharmacogenetic Testing

被引：36

作者：

Ikediobi, O. N. ^{[1
]}

Shin, J. ^{[1
]}

Nussbaum, R. L. ^{[2
]}

Phillips, K. A. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Pharm, Dept Clin Pharm, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94143 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 01期

关键词：

IRINOTECAN; NEUTROPENIA; GENE;

D O I：

10.1038/clpt.2009.30

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Pharmacogenomics aims to use molecular genetic markers to predict treatment outcome. Indeed, within the past decade there has been a rapid emergence of pharmacogenetic tests to aid clinicians in predicting efficacy or toxicity for some drugs. Despite this major advance in therapeutic drug management, there remain challenges to the appropriate use of pharmacogenetic tests. We discuss UGT1A1 pharmacogenetic testing to illustrate the knowledge gaps impeding widespread use of pharmacogenetic tests in the clinical setting.

引用

页码：28 / 31

页数：4

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