Biomarkers for the development of cancer vaccines - Current status

被引：14

作者：

Copier, John

Whelan, Mike

Dalgleish, Angus

机构：

[1] St Georges Univ London, Dept Oncol, Div Cellular & Mol Med, London SW17 0RE, England

[2] St Georges Univ London, Onyvax Ltd, London, England

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2006年 / 10卷 / 06期

关键词：

D O I：

10.1007/BF03256210

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Significant improvements in our knowledge of tumor immunology have resulted in more sophisticated vaccine approaches for the treatment of cancer. However, research into biomarkers that correlate with the clinical outcome of immunotherapy has lagged behind vaccine development. To this extent, very few immunological or other markers exist that can be used in clinical trials for immunotherapy. In this review, we discuss the current status of biomarker development specifically for the monitoring and development of cancer vaccines. This includes immunological biomarkers (measurement of T-cell and cytokine responses), autoimmunity as a correlate for treatment outcome, and the possible development of multiple biomarkers using high-throughput proteomics technologies. The generation of such biomarkers will allow us to make clinical decisions about patient treatment at an earlier stage and should aid in shortening the development time for vaccines.

引用

页码：337 / 343

页数：7

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