Monodentate phosphines provide highly active catalysts for Pd-catalyzed C-N bond-forming reactions of heteroaromatic halides/amines and (H)N-heterocycles

被引：291

作者：

Anderson, Kevin W. ^{[1
]}

Tundel, Rachel E. ^{[1
]}

Ikawa, Takashi ^{[1
]}

Altman, Ryan A. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 39期

关键词：

amination; chemoselectivity; palladium; phosphines;

D O I：

10.1002/anie.200601612

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A good alternative: Highly reactive catalysts based on palladium and dialkylbiarylphosphino ligands provide unprecedented reactivity and selectivity in C-N bond-forming processes. The bulky monophosphine catalyst system Pd/1 was effective for the reaction of aryl/heteroaryl halides bearing primary amides and 2-aminoheterocycles (see scheme; dba = dibenzylideneacetone, R = CONH2, NH2), thus showing that monodentate phosphines are viable alternatives to, and sometimes superior to, chelating ligands. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6523 / 6527

页数：5

共 40 条

[1] A modified synthesis of iodoazidoaryl prazosin [J].