Stress signalling pathways that impair prefrontal cortex structure and function

被引：2194

作者：

Arnsten, Amy F. T. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 06期

关键词：

SPATIAL WORKING-MEMORY; CATECHOL-O-METHYLTRANSFERASE; CORTICAL NEURONAL RESPONSES; EXCITATORY SYNAPTIC INPUTS; DEPENDENT PROTEIN-KINASE; DENDRITIC MORPHOLOGY; UNCONTROLLABLE STRESS; DOPAMINE-RECEPTORS; PYRAMIDAL NEURONS; FEAR EXTINCTION;

D O I：

10.1038/nrn2648

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The prefrontal cortex (PFC) - the most evolved brain region - subserves our highest-order cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental effects of stress exposure. Even quite mild acute uncontrollable stress can cause a rapid and dramatic loss of prefrontal cognitive abilities, and more prolonged stress exposure causes architectural changes in prefrontal dendrites. Recent research has begun to reveal the intracellular signalling pathways that mediate the effects of stress on the PFC. This research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.

引用

页码：410 / 422

页数：13

共 169 条

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