Scavenging of hypochlorous acid by carvedilol and ebselen in vitro

被引：41

作者：

Aruoma, OI

机构：

[1] Pharmacology Group, University of London King's College

来源：

GENERAL PHARMACOLOGY | 1997年 / 28卷 / 02期

关键词：

carvedilol; hypochlorous acid; ebselen; glutathione peroxidase; antioxidants; inflammation; antihypertensive drug;

D O I：

10.1016/S0306-3623(96)00232-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The antihypertensive drug carvedilol and the antiinflammatory selenoorganic compound ebselen were tested for their ability to react with the reactive oxygen species hypochlorous acid (HOCl) in vitro. 2. Carvedilol scavenges HOCl at a rate sufficient to protect a model molecule catalase against inactivation by HOCl. 3. Ebselen was resistant to HOCl when its glutathione peroxidase mimetic property was compared with that of glutathione peroxidase. Copyright (C) 1997 Elsevier Science Inc.

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收藏

页码：269 / 272

页数：4

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