Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia

被引：104

作者：

Ikeya, Y ^{[1
]}

Takeda, S ^{[1
]}

Tunakawa, M ^{[1
]}

Karakida, H ^{[1
]}

Toda, K ^{[1
]}

Yamaguchi, T ^{[1
]}

Aburada, M ^{[1
]}

机构：

[1] Tsumura & Co, Div Res, Ibaraki 3001192, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 07期

关键词：

Polygala tenuifolia; tenuifoliside B; memory; passive avoidance performance; potassium cyanide (KCN); anoxia;

D O I：

10.1248/bpb.27.1081

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia WILLDENOW, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of R tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound I has cognitive improving and cerebral protective effects.

引用

页码：1081 / 1085

页数：5

共 29 条

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EFFECTS OF HYPOXIA ON MEMORY CONSOLIDATION - IMPLICATIONS FOR A MULTISTAGE MODEL OF MEMORY [J].