Regulation of neuronal survival by the serine-threonine protein kinase Akt

被引：2154

作者：

Dudek, H

Datta, SR

Franke, TF

Birnbaum, MJ

Yao, RJ

Cooper, GM

Segal, RA

Kaplan, DR

Greenberg, ME

机构：

[1] CHILDRENS HOSP,DEPT NEUROL,DIV NEUROSCI,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT NEUROBIOL,BOSTON,MA 02115

[3] MCGILL UNIV,MONTREAL NEUROL INST,MONTREAL,PQ H3A 2B4,CANADA

[4] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV SIGNAL TRANSDUCTION,BOSTON,MA 02115

[5] HARVARD UNIV,SCH MED,DEPT CELL BIOL,BOSTON,MA 02115

[6] UNIV PENN,SCH MED,HOWARD HUGHES MED INST,PHILADELPHIA,PA 19104

[7] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[8] BETH ISRAEL HOSP,DEPT NEUROL,BOSTON,MA 02115

[9] DANA FARBER CANC INST,DIV MOL GENET,BOSTON,MA 02115

来源：

SCIENCE | 1997年 / 275卷 / 5300期

关键词：

D O I：

10.1126/science.275.5300.661

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70(S6K)). Experiments with pharmacological inhibitors, as well as expression of wild-type and dominant-inhibitory forms of Akt, demonstrated that Akt but not p70(S6K) mediates PI3-K-dependent survival. These findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.

引用

页码：661 / 665

页数：5

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