Central α-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits

被引:44
作者
Matsumura, K [1 ]
Tsuchihashi, T [1 ]
Abe, I [1 ]
Iida, M [1 ]
机构
[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Higashi Ku, Fukuoka 8128582, Japan
关键词
agouti-related protein; alpha-melanocyte-stimulating hormone; central nervous system; melanocortin-4; receptor; sympathetic nervous system;
D O I
10.1016/S0006-8993(02)03045-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Intracerebroventricular injection of alpha-melanocyte-stimulating hormone (alpha-MSH) elicited increases in arterial pressure and renal sympathetic nerve activity in conscious rabbits. Pretreatment with intracerebroventricular injection of agouti-related protein, an endogenous melanocortin-3 and 4 receptor antagonist, prevented cardiovascular and sympathetic responses to alpha-MSH. Pretreatment with intraccrebroventricular injection of JKC-363, a synthetic specific melanocortin-4 receptor antagonist, also prevented cardiovascular and sympathetic responses to alpha-MSH In contrast, intravenous alpha-MSH (1 nmol) failed to cause any cardiovascular responses. These results suggest that intracerebroventricularly administered alpha-MSH acts at the melanocortin-4 receptor in the brain and activates sympathetic outflow, resulting in an increase in arterial pressure. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:145 / 148
页数:4
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