Enzymes - By chance, or by design?

被引:50
作者
Ball, P
机构
[1] consultant editor for Nature,
关键词
D O I
10.1038/431396a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Enzymes are well known for speeding up reactions. But have they evolved to use quantum mechanics to exert their effects? Philip Ball meets the researchers who are trying to find out.
引用
收藏
页码:396 / 397
页数:2
相关论文
共 9 条
[1]   Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase - Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes [J].
Basran, J ;
Sutcliffe, MJ ;
Scrutton, NS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (27) :24581-24587
[2]   HYDROGEN TUNNELING IN ENZYME-REACTIONS [J].
CHA, Y ;
MURRAY, CJ ;
KLINMAN, JP .
SCIENCE, 1989, 243 (4896) :1325-1330
[3]   The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling [J].
Doll, KM ;
Bender, BR ;
Finke, RG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (36) :10877-10884
[4]   A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions:: The β-neopentylcobalamin system combined with prior adocobalamin data [J].
Doll, KM ;
Finke, RG .
INORGANIC CHEMISTRY, 2003, 42 (16) :4849-4856
[5]   Proton-coupled electron transfer in soybean lipoxygenase [J].
Hatcher, E ;
Soudackov, AV ;
Hammes-Schiffer, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (18) :5763-5775
[6]   How important are quantum mechanical nuclear motions in enzyme catalysis? [J].
Hwang, JK ;
Warshel, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (47) :11745-11751
[7]   Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase [J].
Kohen, A ;
Cannio, R ;
Bartolucci, S ;
Klinman, JP .
NATURE, 1999, 399 (6735) :496-499
[8]   Enzyme catalysis: Beyond classical paradigms [J].
Kohen, A ;
Klinman, JP .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (07) :397-404
[9]   A new conceptual framework for enzyme catalysis - Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes [J].
Sutcliffe, MJ ;
Scrutton, NS .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (13) :3096-3102