Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?

被引：79

作者：

Nattel, S

机构：

[1] Univ Montreal, Montreal Heart Inst, Dept Med, Montreal, PQ H1T 1C8, Canada

[2] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada

[3] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

[4] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

来源：

CARDIOVASCULAR RESEARCH | 2002年 / 54卷 / 02期

基金：

加拿大健康研究院;

关键词：

antiarrhythmic agents; arrhythmia (mechanisms); gene expression; ion channels; remodeling;

D O I：

10.1016/S0008-6363(01)00562-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is a very common clinical problem. and presently available treatment options are suboptimal. A tremendous amount has been learned over the past 10 years about the atrial substrates that support sustained AF at the tissue, ionic and molecular levels. This understanding of the fundamental mechanisms underlying AF has opened Lip a variety of new, rationally-based therapeutic approaches. The present paper reviews what is known about the mechanistic substrates that lead to AF and discusses the potential therapeutic consequences. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：347 / 360

页数：14

共 166 条

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