Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis

被引：7

作者：

Cripps, AW ^{[1
]}

Foxwell, R ^{[1
]}

Kyd, J ^{[1
]}

机构：

[1] Univ Canberra, Gadi Res Ctr Hlth & Med Sci, Canberra, ACT 2601, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(02)00373-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of protein-polysaccharide conjugate vaccines has had a major impact on Haemophilus influenzae type b disease. The application of this technology to Neisseria meningitidis is also striking, particularly for serogroup C. However, significant challenges exist for the development of vaccines against non-typeable H. influenzae and against N. meningitidis serogroup B. Issues such as non-vaccine-strain replacement and correlates of protection need to be addressed as well as the longer-term implications of vaccination against what are essentially 'normal' microflora. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：553 / 557

页数：5

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