Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes

被引：52

作者：

Coles, Mark C.

Veiga-Fernandes, Henrique

Foster, Katie E.

Norton, Trisha

Pagakis, Stamatis N.

Seddon, Ben

Kioussis, Dimitris

机构：

[1] Natl Inst Med Res, Div Mol Immunol, London NW7 1AA, England

[2] Natl Inst Med Res, Div Immune Cell Biol, London NW7 1AA, England

[3] Natl Inst Med Res, Confocal Microscopy & Image Anal Lab, London NW7 1AA, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 36期

基金：

英国医学研究理事会;

关键词：

imaging; lymphoid organogenesis; transgenic mice;

D O I：

10.1073/pnas.0604183103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2r gamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2r gamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR+ T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.

引用

页码：13457 / 13462

页数：6

共 43 条

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