TIS11 Family Proteins and Their Roles in Posttranscriptional Gene Regulation

被引：83

作者：

Baou, Maria ^{[1
,2
]}

Jewell, Andrew ^{[3
,4
]}

Murphy, John J. ^{[1
]}

机构：

[1] Kings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England

[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 7RH, Leics, England

[3] Kingston Univ, Fac Hlth & Social Care Sci, London SW17 0RE, England

[4] St George Hosp, Sch Med, London SW17 0RE, England

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2009年

关键词：

AU-RICH ELEMENT; ZINC-FINGER PROTEINS; MESSENGER-RNA DECAY; EARLY RESPONSE GENE; TETRADECANOYL PHORBOL ACETATE; KINASE-ACTIVATED PROTEIN-KINASE-2; LYMPHOCYTIC-LEUKEMIA CELLS; COLONY-STIMULATING FACTOR; TRISTETRAPROLIN FAMILY; BINDING-PROTEIN;

D O I：

10.1155/2009/634520

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their 3' untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases. Copyright (C) 2009

引用

页数：11

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