Neural dynamics and the fundamental mechanisms of event-related brain potentials

被引:199
作者
Shah, AS
Bressler, SL
Knuth, KH
Ding, MZ
Mehta, AD
Ulbert, I
Schroeder, CE
机构
[1] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
[2] Nathan S Kline Inst Psychiat Res, Cognit Neurosci & Schizophrenia Program, Orangeburg, NY 10962 USA
[3] Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USA
[4] NASA, Computat Sci Div, Ames Res Ctr, Moffett Field, CA 94035 USA
[5] Cornell Univ, Weill Med Coll, Dept Neurol Surg, New York, NY 10021 USA
[6] Hungarian Acad Sci, Inst Psychol, H-1394 Budapest, Hungary
关键词
current source density (CSD); evoked response; phase resetting; oscillatory activity; single-trial analyses; synchronization;
D O I
10.1093/cercor/bhh009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Event-related potentials (ERPs) provide a critical link between the hemodynamic response, as measured by functional magnetic resonance imaging, and the dynamics of the underlying neuronal activity. Single-trial ERP recordings capture the oscillatory activity that are hypothesized to underlie both communication between brain regions and amplified processing of behaviorally relevant stimuli. However, precise interpretations of ERPs are precluded by uncertainty about their neural mechanisms. One influential theory holds that averaged sensory ERPs are generated by partial phase resetting of ongoing electroencephalographic oscillations, while another states that ERPs result from stimulus-evoked neural responses. We formulated critical predictions of each theory and tested these using direct, intracortical analyses of neural activity in monkeys. Our findings support a predominant role for stimulus-evoked activity in sensory ERP generation, and they outline both logic and methodology necessary for differentiating evoked and phase resetting contributions to cognitive and motor ERPs in future studies.
引用
收藏
页码:476 / 483
页数:8
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