Gankyrin: a new oncoprotein and regulator of pRb and p53

被引：79

作者：

Dawson, Simon

Higashitsuji, Hiroaki

Wilkinson, Anthony J.

Fujita, Jun

Mayer, R. John ^{[1
]}

机构：

[1] Univ Nottingham, Sch Med, Queens Med Ctr, Sch Biomed Sci, Nottingham NG7 2UH, England

[2] Kyoto Univ, Grad Sch Med, Dept Clin Mol Biol, Sakyo Ku, Kyoto 6068507, Japan

[3] Univ York, Dept Chem, Struct Biol Lab, York YO10 5YW, N Yorkshire, England

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 05期

基金：

日本学术振兴会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tcb.2006.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gankyrin is a new oncoprotein with potent cell cycle and apoptotic properties that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2. Purified preparations of the 26S proteasome contain gankyrin, which specifically interacts with the S6b (Rpt3) ATPase of the 19S regulator. In conclusion, gankyrin is a small versatile cell cycle regulator that illustrates the essential interplay between the ubiquitin proteasome system and gene expression in the cell. Here, we discuss the activities of gankyrin and present a model for its function in the regulation of pRb and p53.

引用

收藏

页码：229 / 233

页数：5

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