Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

被引：87

作者：

Collin, Fideline ^{[1
]}

Duval, Xavier ^{[2
,3
,4
,5
]}

Le Moing, Vincent ^{[6
,7
]}

Piroth, Lionel ^{[8
]}

Al Kaied, Firas ^{[3
]}

Massip, Patrice ^{[9
]}

Villes, Virginie ^{[10
,11
,12
]}

Chene, Genevieve ^{[13
]}

Raffi, Francois ^{[14
]}

机构：

[1] Univ Victor Segalen Bordeaux 2, INSERM, U897, F-33076 Bordeaux, France

[2] INSERM, U738, Paris, France

[3] Univ Paris 07, Paris 7, France

[4] Hop Bichat Claude Bernard, AP HP, CIC 07, F-75877 Paris, France

[5] Hop Bichat Claude Bernard, AP HP, Serv Malad Infect, F-75877 Paris 18, France

[6] CHU Montpellier, Hop Gui Chauliac, Serv Malad Infect & Trop, Montpellier, France

[7] Univ Montpellier 1, UMR 145, F-34006 Montpellier, France

[8] CHU Dijon, Serv Malad Infect & Trop, Dijon, France

[9] Hop Purpan, Serv Malad Infect & Trop, Toulouse, France

[10] INSERM, U912, SE4S, F-13258 Marseille, France

[11] Univ Aix Marseille, IRD, UMR S912, Marseille, France

[12] ORS PACA, Marseille, France

[13] Univ Victor Segalen Bordeaux 2, Bordeaux, France

[14] Univ Nantes, Nantes, France

来源：

AIDS | 2009年 / 23卷 / 08期

关键词：

HIV-INFECTED PATIENTS; MINERAL DENSITY; ANTIRETROVIRAL THERAPY; DISEASE;

D O I：

10.1097/QAD.0b013e3283292195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone firactures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.

引用

页码：1021 / 1024

页数：4

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