Genomic signatures of human versus avian influenza a viruses

被引：214

作者：

Chen, Guang-Wu ^{[1
]}

Chang, Shih-Cheng ^{[1
]}

Mok, Chee-Keng ^{[1
]}

Lo, Yu-Luan ^{[1
]}

Kung, Yu-Nong ^{[1
]}

Huang, Ji-Hung ^{[1
]}

Shih, Yun-Han ^{[1
]}

Wang, Ji-Yi ^{[1
]}

Chiang, Chiayn ^{[1
]}

Chen, Chi-Jene ^{[1
]}

Shih, Shin-Ru ^{[1
]}

机构：

[1] Chang Gung Univ, Taoyuan, Taiwan

来源：

EMERGING INFECTIOUS DISEASES | 2006年 / 12卷 / 09期

关键词：

D O I：

10.3201/eid1209.060276

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Position-specific entropy profiles created from scanning 306 human and 95 avian influenza A viral genomes showed that 228 of 4,591 amino acid residues yielded significant differences between these 2 viruses. We subsequently used 15,785 protein sequences from the National Center for Biotechnology Information (NCBI) to assess the robustness of these signatures and obtained 52 "species-associated" positions. Specific mutations on those points may enable an avian influenza virus to become a human virus. Many of these signatures are found in NP, PA, and PB2 genes (viral ribonucleoproteins [RNPs]) and are mostly located in the functional domains related to RNP-RNP interactions that are important for viral replication. Upon inspecting 21 human-isolated avian influenza viral genomes from NCBI, we found 19 that exhibited >= 1 species-associated residue changes; 7 of them contained >= 2 substitutions. Histograms based on pairwise sequence comparison showed that NP disjointed most between human and avian influenza viruses, followed by PA and PB2.

引用

页码：1353 / 1360

页数：8

共 36 条

[1] Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2) [J].