Phosphate-assisted peptide ligation

被引：24

作者：

Thomas, Gemma L. ^{[1
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Biol Sci, Sydney, NSW 2006, Australia

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 28期

关键词：

NATIVE CHEMICAL LIGATION; CYSTEINE-FREE PEPTIDE; GLYCOPEPTIDE SYNTHESIS; STAUDINGER LIGATION; STRATEGIES; PHOSPHOPEPTIDES; AMINOACYLATION; THIOESTER; PROTEINS; VALINE;

D O I：

10.1039/b906492c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

引用

页码：4260 / 4262

页数：3

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