Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs

被引：118

作者：

Sampson, SL

Dascher, CC

Sambandamurthy, VK

Russell, RG

Jacobs, WR

Bloom, BR

Hondalus, MK

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA

[3] Albert Einstein Coll Med, Bronx, NY 10461 USA

[4] Georgetown Univ, Dept Pathol, Lombardi Canc Ctr, Washington, DC 20057 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 05期

关键词：

D O I：

10.1128/IAI.72.5.3031-3037.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The DeltaleuD DeltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.

引用

页码：3031 / 3037

页数：7

共 33 条

[1]

[Anonymous], 1891, Dtsch Med Wschr, DOI [10.1055/s-0029-1206198, DOI 10.1055/S-0029-1206198]

[2] DISSEMINATED BACILLE CALMETTE-GUERIN INFECTION IN AN AIDS PATIENT 30 YEARS AFTER BCG VACCINATION [J].