A dual function anti-leukemic agent with anti-thrombotic activity

被引：13

作者：

Tibbles, H ^{[1
]}

Vassilev, A ^{[1
]}

Uckun, FM ^{[1
]}

机构：

[1] Parker Hughes Inst, Parker Hughes Canc Ctr, St Paul, MN 55113 USA

来源：

LEUKEMIA & LYMPHOMA | 2002年 / 43卷 / 05期

关键词：

platelet; shape change; BTK; LFM-A13;

D O I：

10.1080/10428190290021650

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Here we report that treatment with the anti-leukemic compound, LFM-Al3 resulted in SYK kinase activation and caused distinct shape changes in platelets. Also provided is electron microscopic evidence that similar shape changes are observed in platelets from XID mice. We propose that LFM-Al3 induces a conformational change in the PH domain of BTK and causes BTK to associate with PIP2 which effects actin bundling and shape change.

引用

页码：1121 / 1127

页数：7

共 37 条

[1] Glycoprotein Ib von Willebrand factor interactions activate tyrosine kinases in human platelets [J].

Asazuma, N ;

Ozaki, Y ;

Satoh, K ;

Yatomi, Y ;

Handa, M ;

Fujimura, Y ;

Miura, S ;

Kume, S .

BLOOD, 1997, 90 (12) :4789-4798

[2] Collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma 2 in platelets independent of the integrin alpha(2)beta(1) [J].

Asselin, J ;

Gibbins, JM ;

Achison, M ;

Lee, YH ;

Morton, LF ;

Farndale, RW ;

Barnes, MJ ;

Watson, SP .

BLOOD, 1997, 89 (04) :1235-1242

[3]

Carpenter KA, 1997, BIOPOLYMERS, V42, P37, DOI 10.1002/(SICI)1097-0282(199707)42:1<37::AID-BIP4>3.0.CO

[4]

2-2

[5] Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus [J].

D'Cruz, OJ ;

Venkatachalam, TK ;

Zhu, ZH ;

Shih, MJ ;

Uckun, FM .

BIOLOGY OF REPRODUCTION, 1998, 59 (03) :503-515

[6] Tyrosine phosphorylation of cortactin associated with Syk accompanies thromboxane analogue-induced platelet shape change [J].

Gallet, C ;

Rosa, JP ;

Habib, A ;

Lebret, M ;

Lévy-Toldano, S ;

Maclouf, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) :23610-23616

[7] α-cyano-N-(2,5-dibromophenyl)-β-hydroxybut-2-enamide [J].

Ghosh, S ;

Uckun, FM .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1999, 55 :1364-1365

[8] MECHANISM OF THE INTERACTION OF HUMAN PLATELET PROFILIN WITH ACTIN [J].

GOLDSCHMIDTCLERMONT, PJ ;

MACHESKY, LM ;

DOBERSTEIN, SK ;

POLLARD, TD .

JOURNAL OF CELL BIOLOGY, 1991, 113 (05) :1081-1089

[9] THE ACTIN-BINDING PROTEIN PROFILIN BINDS TO PIP2 AND INHIBITS ITS HYDROLYSIS BY PHOSPHOLIPASE-C [J].

GOLDSCHMIDTCLERMONT, PJ ;

MACHESKY, LM ;

BALDASSARE, JJ ;

POLLARD, TD .

SCIENCE, 1990, 247 (4950) :1575-1578

[10]

Hagmann J, 1998, J CELL SCI, V111, P2181

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