Sound Strategies for Hearing Restoration

被引：198

作者：

Geleoc, Gwenaelle S. G. ^{[1
]}

Holt, Jeffrey R. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Otolaryngol,FM Kirby Neurobiol Ctr, Boston, MA 02114 USA

来源：

SCIENCE | 2014年 / 344卷 / 6184期

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; MOUSE INNER-EAR; MEDIATED GENE-THERAPY; AUDITORY HAIR-CELLS; IN-VITRO; NEURONAL DIFFERENTIATION; COCHLEAR IMPLANT; SUPPORTING CELLS; HUMAN DEAFNESS; EXPRESSION;

D O I：

10.1126/science.1241062

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Hearing loss is the most common sensory deficit in humans, with some estimates suggesting up to 300 million affected individuals worldwide. Both environmental and genetic factors contribute to hearing loss and can cause death of sensory cells and neurons. Because these cells do not regenerate, the damage tends to accumulate, leading to profound deafness. Several biological strategies to restore auditory function are currently under investigation. Owing to the success of cochlear implants, which offer partial recovery of auditory function for some profoundly deaf patients, potential biological therapies must extend hearing restoration to include greater auditory acuity and larger patient populations. Here, we review the latest gene, stem-cell, and molecular strategies for restoring auditory function in animal models and the prospects for translating these approaches into viable clinical therapies.

引用

页码：596 / +

页数：9

共 84 条

[1]

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy [J].

Akil, Omar ;

Seal, Rebecca P. ;

Burke, Kevin ;

Wang, Chuansong ;

Alemi, Aurash ;

During, Matthew ;

Edwards, Robert H. ;

Lustig, Lawrence R. .

NEURON, 2012, 75 (02) :283-293

[2]

[Anonymous], 2011, 29 YEARS OLD HEARING

[3]

Neurotrophin Gene Therapy for Sustained Neural Preservation after Deafness [J].

Atkinson, Patrick J. ;

Wise, Andrew K. ;

Flynn, Brianna O. ;

Nayagam, Bryony A. ;

Hume, Clifford R. ;

O'Leary, Stephen J. ;

Shepherd, Robert K. ;

Richardson, Rachael T. .

PLOS ONE, 2012, 7 (12)

[4]

Math1:: An essential gene for the generation of inner ear hair cells [J].

Bermingham, NA ;

Hassan, BA ;

Price, SD ;

Vollrath, MA ;

Ben-Arie, N ;

Eatock, RA ;

Bellen, HJ ;

Lysakowski, A ;

Zoghbi, HY .

SCIENCE, 1999, 284 (5421) :1837-1841

[5]

A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene [J].

Bitner-Glindzicz, M ;

Lindley, KJ ;

Rutland, P ;

Blaydon, D ;

Smith, VV ;

Milla, PJ ;

Hussain, K ;

Furth-Lavi, J ;

Cosgrove, KE ;

Shepherd, RM ;

Barnes, PD ;

O'Brien, RE ;

Farndon, PA ;

Sowden, J ;

Liu, XZ ;

Scanlan, MJ ;

Malcolm, S ;

Dunne, MJ ;

Aynsley-Green, A ;

Glaser, B .

NATURE GENETICS, 2000, 26 (01) :56-60

[6]

Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea [J].

Bramhall, Naomi F. ;

Shi, Fuxin ;

Arnold, Katrin ;

Hochedlinger, Konrad ;

Edge, Albert S. B. .

STEM CELL REPORTS, 2014, 2 (03) :311-322

[7]

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea [J].

Chai, Renjie ;

Kuo, Bryan ;

Wang, Tian ;

Liaw, Eric J. ;

Xia, Anping ;

Jan, Taha A. ;

Liu, Zhiyong ;

Taketo, Makoto M. ;

Oghalai, John S. ;

Nusse, Roeland ;

Zuo, Jian ;

Cheng, Alan G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (21) :8167-8172

[8]

Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea [J].

Chai, Renjie ;

Xia, Anping ;

Wang, Tian ;

Jan, Taha Adnan ;

Hayashi, Toshinori ;

Bermingham-McDonogh, Olivia ;

Cheng, Alan Gi-Lun .

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2011, 12 (04) :455-469

[9]

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors [J].

Chen, Wei ;

Jongkamonwiwat, Nopporn ;

Abbas, Leila ;

Eshtan, Sarah Jacob ;

Johnson, Stuart L. ;

Kuhn, Stephanie ;

Milo, Marta ;

Thurlow, Johanna K. ;

Andrews, Peter W. ;

Marcotti, Walter ;

Moore, Harry D. ;

Rivolta, Marcelo N. .

NATURE, 2012, 490 (7419) :278-+

[10]

Human Fetal Auditory Stem Cells Can Be Expanded In Vitro and Differentiate Into Functional Auditory Neurons and Hair Cell-Like Cells [J].

Chen, Wei ;

Johnson, Stuart L. ;

Marcotti, Walter ;

Andrews, Peter W. ;

Moore, Harry D. ;

Rivolta, Marcelo N. .

STEM CELLS, 2009, 27 (05) :1196-1204

← 1 2 3 4 5 6 7 8 9 →