Cardiovascular Complications of Obstructive Sleep Apnea Syndrome: Evidence from Children

被引：150

作者：

Bhattacharjee, Rakesh

Kheirandish-Gozal, Leila

Pillar, Giora

Gozal, David ^{[1
]}

机构：

[1] Univ Louisville, Kosair Childrens Hosp, Res Inst, Div Pediat Sleep Med,Dept Pediat, Louisville, KY 40202 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2009年 / 51卷 / 05期

基金：

美国国家卫生研究院;

关键词：

POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; QUALITY-OF-LIFE; CHRONIC-INTERMITTENT HYPOXIA; SYMPATHETIC-NERVE ACTIVITY; AMBULATORY BLOOD-PRESSURE; PULSE TRANSIT-TIME; PERIPHERAL ARTERIAL TONOMETRY; VASCULAR ENDOTHELIAL FUNCTION; LEUKOTRIENE MODIFIER THERAPY;

D O I：

10.1016/j.pcad.2008.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obstructive Sleep Apnea Syndrome (OSAS) is a common condition in children, and is characterized by intermittent partial or complete occlusion of the upper airway during sleep, leading to profound disturbances in homeostatic gas exchange, frequent arousals and disturbed sleep architecture. Pediatric OSAS is associated with a multitude of end-organ morbidities, most of which have been uncovered in the last decade. Of particular interest are the cardiovascular complications that may develop in children with OSAS, since they are posited to have not only an immediately significant impact on cardiovascular health during childhood, but may also affect cardiovascular outcomes later during adult life. In this review, we will present the specific cardiovascular complications that have thus far been described in children with OSAS, with reference to pertinent mechanisms, and potential implications. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：416 / 433

页数：18

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