The role of vitamin D in reducing cancer risk and progression

被引：1125

作者：

Feldman, David ^{[1
]}

Krishnan, Aruna V. ^{[1
]}

Swami, Srilatha ^{[1
]}

Giovannucci, Edward ^{[2
,3
]}

Feldman, Brian J. ^{[4
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Endocrinol, Stanford, CA 94305 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[4] Stanford Univ, Sch Med, Dept Pediat, Div Pediat Endocrinol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CIRCULATING 25-HYDROXYVITAMIN D; D-RECEPTOR EXPRESSION; RANDOMIZED CONTROLLED-TRIAL; INITIATIVE WHI CALCIUM; PATHWAY GENE VARIANTS; HIGH-DOSE CALCITRIOL; D-BINDING PROTEIN; D POOLING PROJECT; PROSTATE-CANCER; BREAST-CANCER;

D O I：

10.1038/nrc3691

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, accumulating results from preclinical and some clinical studies strongly suggest that vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome.

引用

页码：342 / 357

页数：16

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