Wall motion of noninfarcted myocardium -: Relationship to regional and global systolic function and to early and late left ventricular dilation

We studied the wall motion of the noninfarcted area and its role in left ventricular remodeling. The study group consisted of 43 patients with a first Q-wave acute myocardial infarction and single-vessel disease. Cardiac catheterization was performed at the first week, and was repeated-six months later. Left ventricular volumes, wall motion at the infarcted and noninfarcted area, ejection fraction and infarction-related artery status were quantified. Hyperkinesia was only found at the first week in 22% of cases, and at the sixth month in 26% of cases. Wall motion at the noninfarcted area correlated with wall motion at the infarcted area (one week: r=0.53 p<0.0001; six months: r=0.52 p=0.01), ejection fraction (one week: r=0.69 p<0.0001; six months: r=0.56 p=0.006), end-diastolic volume (one week. r=-0.48 p=0.002; six months: r=-0.48 p=0.02) and end-systolic volume (one week:,r=-0.70 p<0.0001; six months: r=-0.63 p=0.001). The improvement of the noninfarcted area (from the first week to the sixth month) was only related to basal (one week) wall motion in this area (r= -0.58 p=0.003). We conclude that after an intermediate-large infarction, most patients exhibit a normal or hypokinetic noninfarcted area. Patients with a more depressed infarcted area show poorer contractility at the noninfarcted area. Hypokinesia at the noninfarcted area is independently related to more enlarged volumes. Those cases with a more depressed noninfarcted area exhibit greater progressive improvement. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.