Monocyte homeostasis and the plasticity of inflammatory monocytes

被引:116
作者
Mitchell, Andrew J. [1 ]
Roediger, Ben [1 ]
Weninger, Wolfgang [1 ,2 ,3 ]
机构
[1] Centenary Inst, Newtown, NSW 2042, Australia
[2] Univ Sydney, Discipline Dermatol, Sydney, NSW 2006, Australia
[3] Royal Prince Alfred Hosp, Dept Dermatol, Camperdown, NSW 2050, Australia
关键词
Monocyte; Macrophage; Homeostasis; Inflammation; COLONY-STIMULATING FACTOR; MONONUCLEAR PHAGOCYTE SYSTEM; TUMOR-ASSOCIATED MACROPHAGES; TISSUE-RESIDENT MACROPHAGES; MARROW-DERIVED MACROPHAGES; SYNTHASE ARGINASE BALANCE; GENE-EXPRESSION PROFILES; HUMAN PERIPHERAL-BLOOD; FACTOR-DEFICIENT MICE; CYTOKINE GM-CSF;
D O I
10.1016/j.cellimm.2014.05.010
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Monocytes are mononuclear myeloid cells that develop in the bone marrow and circulate within the bloodstream. Although they have long been argued to play a role in the repopulation of tissue-resident macrophages, this has been questioned by numerous recent studies, which has forced a reappraisal of their biology. Here we discuss monocyte development, as well as the homeostatic control of monocyte subpopulations within the blood. We also outline the known functions of monocyte subsets. Finally, we highlight the plastic nature of monocytes, which are capable of a remarkable range of phenotypic and functional changes that depend on signals from local microenvironments. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:22 / 31
页数:10
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