An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

被引：185

作者：

Moreira, Paula I. ^{[2
]}

Duarte, Ana I. ^{[3
]}

Santos, Maria S. ^{[3
]}

Rego, A. Cristina

Oliveira, Catarina R. ^{[1
]}

机构：

[1] Univ Coimbra, Ctr Neurosci & Cell Biol, Inst Biochem, Fac Med, P-3004517 Coimbra, Portugal

[2] Univ Coimbra, Inst Physiol, Fac Med, P-3004517 Coimbra, Portugal

[3] Univ Coimbra, Dept Zool, Fac Sci & Technol, P-3004517 Coimbra, Portugal

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 16卷 / 04期

关键词：

Alzheimer's disease; glucose metabolism; insulin; mitochondria; oxidative stress; AMYLOID-BETA-PEPTIDE; MILD COGNITIVE IMPAIRMENT; CENTRAL-NERVOUS-SYSTEM; ALPHA-KETOGLUTARATE DEHYDROGENASE; CEREBRAL GLUCOSE-METABOLISM; GROWTH-FACTOR EXPRESSION; CYTOCHROME-C-OXIDASE; PERMEABILITY TRANSITION PORE; TRANSGENIC MOUSE MODEL; BLOOD-BRAIN-BARRIER;

D O I：

10.3233/JAD-2009-0972

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The processes underlying the pathogenesis of Alzheimer's disease involve several factors including impaired glucose/energy metabolism, mitochondrial dysfunction, oxidative stress and altered insulin-signaling pathways. This review is mainly devoted to discuss evidence supporting the notion that mitochondrial dysfunction and oxidative stress are interconnected and intimately associated with the development and progression of Alzheimer's disease. Furthermore, the review explores the role of insulin signaling in the pathophysiology of the disease. Indeed, several studies have begun to find links between insulin and mechanisms with clear pathogenic implications for this disorder. Understanding the key mechanisms involved in the etiopathogenesis of Alzheimer's disease may provide opportunities for the design of efficacious preventive and therapeutic strategies.

引用

页码：741 / 761

页数：21

共 231 条

[1]

β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [J].