Properties of fluorophores on solid phase resins; Implications for screening, encoding and reaction monitoring.

被引：25

作者：

Scott, RH ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1TN,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 12期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(97)00263-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fluorescent molecules covalently attached to resin beads are analysed to explore the application of on-bead fluorescence in combinatorial chemistry, and in particular: screening, encoding and reaction monitoring. The range of linearity of on-bead fluorescence is shown to be dependent on both the extent of loading and the Stokes shift of the fluorophore. Spectral deconvolution of multiple fluorophores on-bead is demonstrated. (C) 1997 Elsevier Science Ltd.

引用

页码：1567 / 1572

页数：6

共 14 条

[1]

ATOR M, 1994, PEPTIDES CHEM STRUCT, P1012

[2]

BRIDGES JW, 1981, DETERMINATION QUANTU, P68

[3] BIASED COMBINATORIAL LIBRARIES - NOVEL LIGANDS FOR THE SH3 DOMAIN OF PHOSPHATIDYLINOSITOL 3-KINASE [J].