Regulation of acetylcholine synthesis and storage

被引：98

作者：

Prado, MAM

Reis, RAM

Prado, VF

de Mello, MC

Gomez, MV

de Mello, FG

机构：

[1] Univ Fed Minas Gerais, ICB, Dept Farmacol, Lab Neurofarmacol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, ICB, Dept Bioquim Imunol, Mol Neurobiol Lab, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil

来源：

NEUROCHEMISTRY INTERNATIONAL | 2002年 / 41卷 / 05期

关键词：

acetylcholine; cholinergic transmission; phosphorylation;

D O I：

10.1016/S0197-0186(02)00044-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Acetylcholine is one of the major modulators of brain functions and it is the main neurotransmitter at the peripheral nervous system. Modulation of acetylcholine release is crucial for nervous system function. Moreover, dysfunction of cholinergic transmission has been linked to a number of pathological conditions. In this manuscript, we review the cellular mechanisms involved with regulation of acetylcholine synthesis and storage. We focus on how phosphorylation of key cholinergic proteins can participate in the physiological regulation of cholinergic nerve-endings. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：291 / 299

页数：9

共 107 条

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Assembly of presynaptic active zones from cytoplasmic transport packets [J].