Mechanisms of roof plate formation in the vertebrate CNS

被引：69

作者：

Chizhikov, VV ^{[1
]}

Millen, KJ ^{[1
]}

机构：

[1] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2004年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrn1520

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.

引用

页码：808 / 812

页数：5

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