A "hidden" co-crystal of caffeine and adipic acid

被引：76

作者：

Bucar, Dejan-Kresimir

Henry, Rodger F.

Lou, Xiaochun

Borchardt, Thomas B.

Zhang, Geoff G. Z. ^{[1
]}

机构：

[1] Abbott Labs, N Chicago, IL 60064 USA

[2] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[3] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 05期

关键词：

D O I：

10.1039/b611749j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Co-crystal formation between caffeine and adipic acid has been explored over the years without success; utilizing the newly developed co-crystal screening method, we have finally discovered this "hidden'' caffeine and adipic acid co-crystal.

引用

页码：525 / 527

页数：3

共 14 条

[1] Building co-crystals with molecular sense and supramolecular sensibility [J].

Aakeröy, CB ;

Salmon, DJ .

CRYSTENGCOMM, 2005, 7 :439-448

[2] The Cambridge Structural Database: a quarter of a million crystal structures and rising [J].

Allen, FH .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2002, 58 (3 PART 1) :380-388

[3] Crystal engineering approach to forming cocrystals of amine hydrochlorides with organic acids. Molecular complexes of fluoxetine hydrochloride with benzoic, succinic, and fumaric acids [J].

Childs, SL ;

Chyall, LJ ;

Dunlap, JT ;

Smolenskaya, VN ;

Stahly, BC ;

Stahly, GP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (41) :13335-13342

[4] SUPRAMOLECULAR SYNTHONS IN CRYSTAL ENGINEERING - A NEW ORGANIC-SYNTHESIS [J].

DESIRAJU, GR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (21) :2311-2327

[5]

Evstratova K I, 1968, Farmatsiia, V17, P33

[6]

EVSTRATOVA KI, 2001, MERCK INDEX

[7] CHARACTERIZATION OF HABITS AND CRYSTALLINE MODIFICATION OF SOLIDS AND THEIR PHARMACEUTICAL APPLICATIONS [J].

HALEBLIAN, JK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (08) :1269-1288

[8]

Kitaigorodskii A. I., 1984, Mixed Crystals

[9] THE INTERACTION OF CAFFEINE WITH SEVERAL ALIPHATIC ORGANIC DIBASIC ACIDS IN SOLID-STATE [J].

NISHIJO, J ;

TAKENAKA, F ;

TANAKA, I .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1980, 100 (07) :732-738

[10] Crystal engineering of novel cocrystals of a triazole drug with 1,4-dicarboxylic acids [J].

Remenar, JF ;

Morissette, SL ;

Peterson, ML ;

Moulton, B ;

MacPhee, JM ;

Guzmán, HR ;

Almarsson, O .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (28) :8456-8457

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