UCbase & miRfunc: a database of ultraconserved sequences and microRNA function

被引：24

作者：

Taccioli, Cristian ^{[1
]}

Fabbri, Enrica ^{[2
]}

Visone, Rosa ^{[1
]}

Volinia, Stefano ^{[1
]}

Calin, George A. ^{[3
]}

Fong, Louise Y. ^{[1
]}

Gambari, Roberto ^{[2
]}

Bottoni, Arianna ^{[1
]}

Acunzo, Mario ^{[4
]}

Hagan, John ^{[1
]}

Iorio, Marilena V. ^{[5
]}

Piovan, Claudia ^{[5
]}

Romano, Giulia ^{[4
]}

Croce, Carlo Maria ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Univ Ferrara, Biochem & Mol Biol Dept, I-44100 Ferrara, Italy

[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[4] Univ Naples Federico 2, Mol Pathol & Biol Dept L Califano, I-80100 Naples, Italy

[5] Natl Tumor Inst, IRCCS Fdn, I-20100 Milan, Italy

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

HUMAN GENOME; EXPRESSION; CANCER; TARGETS; CARCINOMAS; LEUKEMIA; RNAS;

D O I：

10.1093/nar/gkn702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.

引用

页码：D41 / D48

页数：8

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