Synthetic applicability and in situ recycling of a B-methoxy oxazaborolidne catalyst derived from cis-1-amino-indan-2-ol

被引：27

作者：

Gilmore, NJ ^{[1
]}

Jones, S ^{[1
]}

Muldowney, MP ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 16期

关键词：

D O I：

10.1021/ol048916o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure is described that greatly simplifies the use of an oxazaborolidine catalyst derived from (1R,2S) cis-1-amino-indan-2-ol. This B-OMe catalyst has been employed in the asymmetric reduction of a number of structurally diverse prochiral ketones, in particular the reduction of alpha-amino acetophenone and its derivatives. A method for reducing the effective catalyst loading by "in situ recycling" is also presented.

引用

页码：2805 / 2808

页数：4

共 26 条

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