Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: a review

被引：42

作者：

Baskaran, Udhaya Lavinya ^{[1
]}

Sabina, Evan Prince ^{[1
]}

机构：

[1] VIT Univ, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India

来源：

JOURNAL OF INTEGRATIVE MEDICINE-JIM | 2017年 / 15卷 / 01期

关键词：

antitubercular agents; isoniazid; rifampicin; pyrazinamide; oxidative stress; complementary therapies; INDUCED HEPATIC-INJURY; MITOCHONDRIAL OXIDATIVE STRESS; ORPHAN NUCLEAR RECEPTORS; INDUCED LIVER-INJURY; PREGNANE X RECEPTOR; N-ACETYLTRANSFERASE-2; GENE; HEPATOPROTECTIVE ACTIVITY; TUBERCULOSIS PATIENTS; ADVERSE EVENTS; NEVIRAPINE USE;

D O I：

10.1016/S2095-4964(17)60319-4

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs (ATDs). There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of several natural and synthetic compounds in minimising this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ATD-induced hepatotoxicity, its underlying mechanisms and alternative therapies for the same.

引用

页码：27 / 36

页数：10

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