Diastereo- and enantioselective carbolithiation of allyl o-lithloaryl ethers.: New chiral cyclopropane derivatives

被引：36

作者：

Barluenga, J

Fañanás, FJ

Sanz, R

Marcos, C

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, CSIC, Unidad Asociada, Oviedo 33701, Spain

[2] Univ Burgos, Dept Quim, Fac Ciencias, Area Quim Organ, Burgos 09001, Spain

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 13期

关键词：

D O I：

10.1021/ol026078x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different allyl 2-lithloaryl ethers undergo a tandem carbolithiation/gamma-elimination in Et2O/TMEDA affording o-cyclopropyl phenol or naphthol derivatives in a diastereoselective manner. The use of (-)-sparteine as a chiral ligand instead of TMEDA allows the synthesis of cyclopropane derivatives with up 81% ee.

引用

页码：2225 / 2228

页数：4

共 52 条

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