Checking that replication breakdown is not terminal

被引:25
作者
Carr, AM [1 ]
机构
[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
关键词
D O I
10.1126/science.1075456
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Two new studies help to clarify the relationship between checkpoint proteins, recombination, and replication fork integrity.
引用
收藏
页码:557 / 558
页数:3
相关论文
共 13 条
[1]   DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints [J].
Bashkirov, VI ;
King, JS ;
Bashkirova, EV ;
Schmuckli-Maurer, J ;
Heyer, WD .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (12) :4393-4404
[2]   Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1 [J].
Boddy, MN ;
Lopez-Girona, A ;
Shanahan, P ;
Interthal, H ;
Heyer, WD ;
Russell, P .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (23) :8758-8766
[3]   ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones [J].
Cha, RS ;
Kleckner, N .
SCIENCE, 2002, 297 (5581) :602-606
[4]   Historical overview: Searching for replication help in all of the rec places [J].
Cox, MM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8173-8180
[5]   The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA [J].
Ivessa, AS ;
Zhou, JQ ;
Zakian, VA .
CELL, 2000, 100 (04) :479-489
[6]   Rescue of stalled replication forks by RecG: Simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation [J].
McGlynn, P ;
Lloyd, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8227-8234
[7]   DNA double-strand breaks caused by replication arrest [J].
Michel, B ;
Ehrlich, SD ;
Uzest, M .
EMBO JOURNAL, 1997, 16 (02) :430-438
[8]  
Muris DFR, 1996, J CELL SCI, V109, P73
[9]   Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance [J].
Murray, JM ;
Lindsay, HD ;
Munday, CA ;
Carr, AM .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) :6868-6875
[10]   Checkpoints: It takes more than time to heal some wounds [J].
Rhind, N ;
Russell, P .
CURRENT BIOLOGY, 2000, 10 (24) :R908-R911